Genome editing refers to the latest generation of genetic engineering techniques, including the tool CRISPR/Cas9, whose discovery was awarded a Nobel Prize in 2020. The application of genome editing to humans raises hopes for new medical therapies. However, the possibility of germline interventions, i.e. permanent, heritable interventions in the human genome, also raises fundamental ethical questions. TAB-Arbeitsbericht Nr. 191 provides an up-to-date, interdisciplinary overview of the extensive discussion on the topic of genome editing in humans.