The vision of drone-based delivery is not without presuppositions. To realise it, many technical and regulatory obstacles have to be overcome. Given the considerable depth of engagement – considering that the airspace around us, which was so far used by birds and occasional helicopters only, would change profoundly – a number of typical technology assessment (TA) questions are on the table: Are there safety concerns? Are there environmental risks? Could criminals or terrorists misuse the technology? Are we in the face of a societal conflict given the divergent interests involved? Does the current regulatory framework suffice, or do we need new rules?